DeskNow lets you set many preferences to personalize your account. Amongst the things you can change:
language of the interface
time zone
date and time formats
start of week
layout (if your site has multiple layouts available - DeskNow has one layout by default but more can be added - ask the administrator for more details)
screen colors ("theme")
font size
disable/enable preview panes
number of rows per page listed
To access your preferences, click on the Preferences link in the menu, and then on the preference group that you want to change.